Peptides are generally widely used in the study of human-related disease mechanisms, while peptide reagents in the field of veterinary medicine have been rarely reported before. The reason is that peptides are relatively expensive drugs and their oral availability is relatively low, so their application in veterinary medicine is limited due to cost and other alternative drugs. With the development of the world economy and the increasingly serious impact of animal-derived diseases on human life, such as swine flu, foot-and-mouth disease, etc., the application of peptides in veterinary medicine with high biological activity, easier metabolism and less side effects have attracted attention.
In addition, compared to the treatment of animal infectious diseases, peptide drugs for pets have a wider market, because owners are willing to pay for drugs and treatments to increase the lifespan and quality of life of sick pets.
Our high-throughput peptidomimetic development platform, PepDomTM, is dedicated to the development of a variety of biologically active peptidomimetics, which will be used in veterinary medicine for the treatment and diagnosis of animal diseases, animal reproductive management, and the development of animal functional feeds.
Application of Peptidomimetics in Veterinary Medicine
Active peptides and their peptidomimetics have more and more extensive application prospects in the field of veterinary medicine, which are reflected in different aspects.
Veterinary Treatment
Antibiotics are commonly used in the treatment of animal diseases, however, they are often prone to drug resistance and have serious side effects. Existing research has found that the mechanism of action of some peptide drugs is different from that of traditional antibiotics. It is not easy to accumulate poisoning, does not cause teratogenicity, and does not lead to the production of drug-resistant strains.
Therefore, it is expected to be developed into a new type of peptide antibiotics, which can be as an effective preventive and therapeutic drug for animal diseases, such as synthetic CAP-18 has curative effect on animal abdominal infection caused by Pseudomonas aeruginosa.
Reproductive Management
Many peptide analogs have been used to regulate animal reproduction. For example, a single injection of GnRH analogs in rabbits induces ovulation and improves pregnancy rates. There are also peptide analogs developed as implants for long-term reproductive management, which facilitate long-term administration and allow for non-surgical sterilization of stray dogs and cats, population control in wildlife and reproductive management in zoos and endangered species.
The application of peptides and their analogs is not limited to animal species. They can act on birds, mammals, aquatic animals, etc., to a large extent, help humans strengthen the control of animal reproduction.
Diagnostic Reagent Development
In daily life, people in many areas suffer serious losses due to the infection of animal viruses. Therefore, the diagnosis and treatment of animal infectious diseases is of great significance to maintain social stability and ensure people's health and safety. Animal infectious diseases are not only human-to-animal infection but also animal-to-animal infection, common infectious diseases such as plague, tularemia, Japanese encephalitis, anthrax, rabies, Lyme disease, brucellosis and so on.
It has been reported that peptides are used to develop diagnostic reagents to rapidly detect corresponding pathogens. For example, avian influenza virus detection kits and swine fever virus detection kits have been developed.
Animal Feed Development
Active peptides and their peptidomimetics are most concerned in veterinary medicine as feed additives to improve animal immunity, prevent animal diseases and promote healthy growth of animals. Since the modified active peptidomimetics can withstand the high temperature of feed pelleting, during large-scale fermentation production, the high-temperature concentration process will not lead to loss of activity, and it has the advantages of large-scale production, short cycle, low cost, and no seasonality. and climate change impacts.
For example, adding liquid silkworm antimicrobial peptide AD-yeast preparation to meat duck diet found that the activity of serum metabolic hormones was significantly enhanced, the concentration of IGF-1 was increased, and the synthesis of nutrients was enhanced.
CD BioSciences is committed to the development of high-throughput peptidomimetics, which are widely used in the field of veterinary medicine. If you have any application or service you want to know about, please do not hesitate to contact us immediately for the best advice and solutions.
References
- Valdez-Miramontes, C. E., De Haro-Acosta, J., Aréchiga-Flores, C. F., Verdiguel-Fernández, L., & Rivas-Santiago, B. (2021). Antimicrobial peptides in domestic animals and their applications in veterinary medicine. Peptides, 142, 170576.
- Van Kimmenade, R. R. J., & Januzzi, J. L. (2009). The evolution of the natriuretic peptides – Current applications in human and animal medicine. Journal of Veterinary Cardiology, 11, S9–S21.
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