Targeting signal molecules to prevent signal transduction will effectively inhibit the proliferation and differentiation of some diseased cells. CD BioSciences provides comprehensive peptidomimetic development services targeting extracellular and intracellular signaling molecules.
Introduction to Signaling Molecules
Signal transduction is the process by which chemical or physical signals are transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately leads to a cellular response. Signal carriers are called signal molecules, which are mainly used to transmit information between and within cells, and to regulate various physiological responses of cells. Therefore, targeting signaling molecules has become one of the effective strategies for the treatment and diagnosis of major diseases.
| Extracellular Signaling Molecules |
Intracellular Signaling Molecules |
- Examples: hormones, local mediators, neurotransmitters.
- Function: Bind to specific receptors located in the cell membrane or cytoplasm to conduct information transduction, thereby initiating a cellular response.
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- Examples: cAMP, cGMP, IP3, DG, Ca2+.
- Function: Carrying and amplifying cellular signals, usually activating an enzyme that causes a series of cellular responses.
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Our Services
There are many polypeptide drugs targeting cell signaling molecules, but they have disadvantages such as poor stability, easy to be hydrolyzed by proteases, and low bioavailability. In order to solve the above deficiencies, CD BioSciences with its advanced PepDomTM peptidomimetic development platform, can develop highly stable peptidomimetics targeting signal molecules, fully satisfying the research requirements of customers.
Advantages of peptidomimetic compounds designed and developed by our PepDomTM platform:
- Higher Stability: resistance to enzymatic hydrolysis by a wide range of proteases in organisms.
- Higher Bioavailability: across biofilms to the site of action.
- Longer in vivo Half-Life: continuous effect, stronger plasma stability.
Our experienced team is dedicated to the development of targeted peptidomimetic of extracellular and intracellular signaling molecules. The signaling molecules we focus on include but are not limited to:
 Extracellular Signaling Molecules |
| Hormones |
Protein and peptide hormones(e.g., Insulin) |
| Steroid hormones (e.g., Estradiol, Testosterone) |
| Amino acid derivative hormones (e.g., Thyroid, Epinephrine) |
| Local mediators |
Growth factors |
| Lymphokines |
| Synaptic secretory signals |
| Neurotransmitters |
Cholines (e.g., Acetylcholine, Acetylcholine) |
| Monoamines (e.g., Dopamine, and Serotonin) |
| Amino acids (e.g., Glutamate, Glycine and Taurine) |
| Neuropeptides |
 Intracellular Signaling Molecules |
| cAMP, cGMP, IP3/DG, Calmodulin, and other molecules involved in intracellular signaling. |
Features of Our Service
We are committed to providing the best solutions for global customers to help save time and cost.
High Quality
Cost Efficient
Customer First
Highly Customizable
CD BioSciences focuses on the development of peptidomimetics targeting various molecules of cell signal transduction. As long as you provide the target you are interested in, our professional team will solve it immediately. Welcome to contact us for the best solution.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
