Peptides are emerging as important cosmetic ingredients with anti-inflammatory properties that reduce premature skin aging, improve skin barrier function, moisturize skin, protect skin from UV damage, and reduce acne and irritation. So far, most peptides have been obtained by chemical synthesis or partial digestion of animal proteins. Short and easily synthesized peptidomimetics with alternative amino acid sequences and their combinations have created a new field of molecules inspired by nature and implemented in the cosmetic industry.
Today, better development techniques allow obtaining a variety of special sequences, which make peptides more functional and more popular in cosmetic development.
We have extensive expertise and long-term experience in peptidomimetic development. Our high-throughput screening platform and ability to modify peptidomimetics make us well-positioned to be the partner of choice for the cosmetic industry.
Application of Peptidomimetics in Cosmetics
Peptides and peptidomimetics have become very important ingredients in cosmetics, especially in anti-aging preparations, and according to their mode of action, they are divided into three major categories: signal peptides, neurotransmitter-affecting peptides and carrier peptides. They are added to cosmetics as various functional ingredients.
Signal Peptidomimetics
Signal peptides with the ability to increase collagen fibroblast production can reduce collagenase breakdown of existing collagen and are used as ingredients in many creams and lotions designed to improve the appearance of aging skin. Peptides introduced with the appropriate amino acid sequence are able to stimulate fibroblasts, stimulating the production of skin proteins that degrade with age. However, due to the special structure of peptides, the stratum corneum is a barrier that they cannot cross, and the development of peptidomimetics can overcome this problem by modifying or removing parts of the structure to allow them to cross the skin barrier.
Neurotransmitters-Affecting Peptidomimetics
Neurotransmitters-Affecting Peptides and Peptidomimetics work to fight wrinkles by blocking the flow of nerve impulses from cells located in the skin to the muscles. Their activity is similar to the mechanism of botulinum toxin injections. Although the effect of this peptide is not as strong as that of botulinum toxin. However, regular use of products containing this compound produces great anti-wrinkle effects. Furthermore, the advantage of therapeutic neuropeptides is that they are not invasive and cause no complications. These peptides have the effect on the skin: moisturizing, firming and reducing roughness.
Carrier Peptidomimetics
Carrier peptides are a small class of peptides that contain a copper molecule in their structure. They have been extensively studied for their ability to promote skin healing of wounds. Carrier peptides and peptidomimetics can break down specific types of tissue (called supersized collagen aggregates) that form scars. When these aggregates are broken down, the wound heals with far less scar tissue. In addition, it provides significant anti-inflammatory benefits. Therefore, they are widely used in scar removal as well as cosmetic products used after surgery.
In addition to the above three, peptidomimetic molecules with special efficacy and structure can also be developed based on the needs of modern consumers to be added to cosmetics in various forms (such as lotions, creams, masks, essences, etc.).
Skin Benefits of Adding Active Peptidomimetics
- Repair damaged skin: Use carrier peptides to repair skin from the inside out
- Removes skin wrinkles: Signals cells to produce more collagen, resulting in firmer skin.
- Reduces skin inflammation: Peptides have anti-inflammatory properties that help soothe and calm the skin.
- Locks in moisture: Replenishes collagen in the skin This helps to lock in skin moisture and reduce moisture loss.
- Strengthen the skin barrier: Enhance the activity of skin cells, thereby strengthening the skin barrier.
CD BioSciences is committed to the development of high-throughput peptidomimetics, which are widely used in the field of cosmetics. If you have any application or service you want to know about, please do not hesitate to contact us immediately for the best advice and solutions.
References
- Skibska A, Perlikowska R. Signal Peptides - Promising Ingredients in Cosmetics. (2021). Curr Protein Pept Sci, 22(10):716-728.
- Sionkowska A, Adamiak K, Musiał K, Gadomska M. Collagen Based Materials in Cosmetic Applications: A Review. (2020). Materials (Basel), 13(19):4217.
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