The discovery of proteases and peptidases that play key roles in tumorigenesis means that peptidomimetics should be highly regarded as potential tumor chemotherapeutics. CD BioSciences is committed to developing a broad range of peptidomimetics with anti-cancer activity to facilitate basic scientific research and drug discovery for customers around the world.
Overview of Anti-Cancer Drugs
In recent years, the focus of the development of cancer therapeutic drugs has shifted from cytotoxic drugs to targeted drugs, and many proteases and peptidases that play a key role in the development of tumorigenesis have been found. This means that peptides have great potential as lead compounds for cancer treatment, and should be highly valued. However, the inherent molecular flexibility and poor bioavailability of natural peptides severely limit their development as anticancer drugs.
Advantages of Anti-Cancer Peptidomimetic
Peptidomimetics, as structural or functional mimics of natural active peptides, can maintain the biological activity of the lead peptide, improve the bioavailability and specificity to the target. In addition, peptidomimetics with high biological activity can be designed in a variety of ways, including conformational restriction, modification and non-peptide design. These small molecules with leading peptide function or structural characteristics play a great role in the process of tumorigenesis, invasion, metastasis, angiogenesis and matrix degradation. Therefore, peptidomimetics based on these small molecules have great potential in developing highly selective chemotherapeutic drugs.
Fig. 1 Brevinin-1BYa and its derivatives as antitumor. (Xiong, et al., 2021)
Our Services
CD BioSciences focuses on helping our customers make greater research progress in the field of cancer drug discovery. Based on the leading peptide mimetic development platform PepDomTM, we provide peptidomimetic development services with anticancer activity according to potential anticancer targets.
- PepDomTM can perform high-throughput screening of anti-cancer active peptidomimetics according to the specific requirements of customers, and further optimize or reorganize the conformation, such as cyclization design, replacement of amino acids, etc. to obtain higher stability.
- PepDomTM can also realize the design of non-peptide segments to replace certain amino acid residues or peptide scaffolds to improve the efficacy and selectivity.
- For structural modification services of natural anti-cancer peptides, please check our Peptidomimetic Modification Service.
Advantages of Our Technology
Natural anticancer peptides, its therapeutic application is limited owing to its poor protease and reduction stability. To date, there are few systematic methods for converting native peptides into peptidomimetics, especially their non-peptides.
- PepDomTM is a technology platform dedicated to high-throughput peptidomimetic development, and our leading technology platform just fills the above gap.
- PepDomTM can build high-capacity nucleic acid libraries and peptide libraries to help customers achieve high-throughput screening based on anticancer activity.
- Our unique technology also enables high stability and high targeting of target peptidomimetics to improve their bioavailability.
This leading technology will serve as the best tool for peptidomimetic development to facilitate the discovery and research of anticancer drugs.
Features of Our Services
Rapid Turnaround
Cost Efficient
High Quality
Customer First
CD BioSciences is always ready to provide the best services to each of our customers. If you are interested in our services or have any specific requirements, please feel free to contact us for more details.
Reference
- Xiong, S., Wang, N., Liu, C., Shen, H., & Zhao, L. (2021). Design, synthesis, and anti-tumor activities of novel brevinin-1bya peptidomimetics. Bioorganic & Medicinal Chemistry Letters, 127831.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
